Persistently Elevated Levels of Serum Autoimmune Inflammatory Markers after Total Thyroidectomy for Hashimoto's Thyroiditis An Indicator of Prevailing Autoimmunity Al-Tamimi Adil Shaker1, Dheeb Israa A2 1Department of Surgery, College of Medicine, University of Al-Qadisiyah, Iraq 2Department of Medical Microbiology, College of Medicine, University of Al-Qadisiyah, Diwaniyah, Iraq Online published on 6 April, 2019. Abstract Hashimoto's thyroiditis characterized by glandular lymphocytic infiltration with progressive parenchyma destruction and fibrosis. The autoimmunity was suggested by the reduced immune tolerance and the production of antibodies. The description of Th17 subpopulation has undesirable role in the pathogenesis of Hashimoto's disease. Among the cytokine secretion of Th17 is cell-type specific which carry its major effectors functions, IL17 and IL 22 are the most important. Fifty two drug native patients with Hashimoto's thyroiditis were enrolled in the study. Preoperative, 6 weeks and 6 months postoperative serum assay of ATPO Ab, IL6, tumor necrosis factor TNF-α, IL17 A, IL22, IL23 was adopted. Surgery in form of total thyriodectomy was carried out for patients with suspicious nodule based on cytological examination or large symptomatic multinodular goiter. The preoperative elevated Anti TPO Ab significantly higher levels than the 6 weeks and 6 months post operative measurement. Serum levels of IL 6 and TNF-α were significantly higher in the preoperative measurement than the 6 weeks post operative measurement, and higher than 6 months serum level for IL6 but not TNF-α. The IL 17A levels were significantly higher in the preoperative patients sera than the 6 wk post operative measurement, but not the 6 months measurement. No statistical difference was observed in the preoperative and post operative levels of IL 22. The preoperative serum Level of IL-23 was apparently high, and significantly different from 6 weeks and 6 months post operative measurement. The measured selected immune parameters exhibit partial decrease in serum level which would not reach the normal circulatory levels 6 months after thyroidectomy. Top Keywords Autoimmunity, Thyroidectomy, Inflammatory Markers. Top |