Phytochemistry and Antibacterial Activity of Cynometra Cauliflora Wahab Noor Zarina Abd1,*, Badya Norhidayah2, Ibrahim Nazlina3, Kamarudin Mohd Khairul Amri4 1Lecturer, Faculty of Health Sciences, Universiti Sultan Zainal Abidin, Malaysia 2Lecturer, Faculty of Medicine, Universiti Sultan Zainal Abidin, Malaysia 3Associate Professor, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Malaysia 4Lecturer, East Coast Environmental Research Institute (ESERI), Universiti Sultan Zainal Abidin, Malaysia *Corresponding author: Noor Zarina Abd Wahab, E-mail: zarinawahab@unisza.edu.my
Online published on 6 April, 2019. Abstract Here we report the potential of Cynometra cauliflora methanolic leaves extract as potential antibacterial agent against clinical isolated microorganisms. Phytochemical analyses reveal the presence of tannin, flavonoid, saponins, cardiac glycosides and terpenoids. In spot test, antibacterial activity can be observed through the formation of zone inhibition of three types of bacteria only which are at concentration of extract used were 75 mg/mL and 100 mg/mL. The MIC was determined ranging from 6.25 mg/mL to 100 mg/mL. The highest value of MIC showed by MRSA which is 6.25 mg/mL. For MBC test, no antibacterial activity have been observed showed that the extract was bacteriostatic which can inhibit the growth of bacteria at concentration less than 100 mg/mL but not kill the bacteria. The results provide evidence that leaves of C. cauliflora extract might indeed be used as a potential source of effective natural antimicrobial agents in pharmaceutical industries. Our findings suggest that C. cauliflora methanolic leaves extract contains antibacterial active compounds and could be potential antibacterial agent. Top Keywords Cynometra cauliflora, phytochemistry, cytotoxicity, antibacterial. Top |