The Relationship between Estimated Glomerular Filtration Rate (EGFR) with Hepcidin in CKD Patients That Have Not Undergone Dialysis Hertanto Decsa Medika1, Ashariati Ami1, Mardiana Nunuk1, Santoso Djoko1,* 1Faculty of Medicine, Airlangga University, Surabaya, 60115, Indonesia *Corresponding author: Djoko Santoso, E-mail: djoko-santoso@fk.unair.ac.id
Online published on 30 April, 2019. Abstract Functional iron deficiency anemia is anemia that often occurs in CKD but is frequently not well diagnosed. Measurement of hepcidin may show an earlier functional iron deficiency status. The relationship between hepcidin and eGFR has not been widely studied. This study is to determine the association between eGFR and hepcidin in patients with CKD who have not undergone dialysis. 37 patient with CKD stage 3 to 5, age 20–80 years old, both male and female gender, who control at Outpatient Clinic of Dr. Soetomo Hospital were the subjects of study. Levels of hepcidin and eGFR were measured in patients with CKD. Sampling is done by consecutive sampling. The data obtained is then analysed using spearman parametric test. The results showed that among 37 subjects, 67.6% were male with average age 56.84 ± 12.27 years. Among them the common cause was hypertension (75%). Stage 3 (43.2%) is the common stage in this study. The mean hemoglobin level in this study was 10.88 ± 2.21 g/dl, with BUN 33.94 ± 21.1 mg/dl, and serum creatinine 3.42 ± 2.25 mg/dl. Average eGFR was 26, 72 ± 16, 12 ml/min/1, 73m2. The median hepcidin level was 48.58 ng/ml (0.12–439.07 ng/ml). eGFR levels correlated negatively with hepcidin level (r =-0.633; p-value 0.000). In conclusion, lower eGFR level is negatively associated with hepcidin level which indicated that when eGFR decreasing, the hepcidin level will be increasing. Top Keywords eGFR, Hepcidin, Anemia, Chronic Kidney Disease. Top |