On Admission Levels of High Sensitive C-Reactive Protein as A Biomarker in Acute Myocardial Infarction: A Case-Control Study Al-hindi Hayder Abdul-Amir Maki1,*, Mousa Mazin Jaafar1, Al-kashwan Thekra Abid Jaber1, Sudan Ahmed1, Abdul-Razzaq Saja Ahmed1 1University of Babylon, Iraq *Corresponding author: Hayder Abdul-Amir Maki Al-hindi, E-mail: makihayder@yahoo.com
Online published on 30 April, 2019. Abstract Atherosclerosis is multi-factorial process, which involves the accumulation of lipid, macrophages and intimal plaques in smooth muscle cell of both large and medium sized arteries. Considerable scientific studies have publicized that inflammation plays a major role in the initiation, progression and destabilization of atheroma. C-reactive protein (CRP) is a non-specific acute phase protein produced by liver in response to injury, infection and inflammation (1). C-reactive protein is an inflammatory marker can be considered as global risk assessment for coronary heart disease (2). The objective of study is to determine the CRP level as risk marker in acute myocardial infarction patients. This was a hospital based cross-sectional study included 68 acute myocardial infarction (AMI) patients aged 30–89 years besides age and sex matched 50 healthy subjects as control group. Blood samples were obtained from both groups and the levels of high sensitive CRP (hs-CRP) have been measured. The current study is an attempt at better understanding the role of hs-CRP in AMI patients. The mean ± SD of serum hs-CRP levels of patients and control subjects were 8.2 ± 7.1 and 0.6 ± 0.4 mg/dl consequently. It was founded that 64% of patients have higher values of CRP and only 4% have high values of CRP in controls with P-value < 0.05, which was found to be significant. Dyslipidemia, a conventional risk factor of AMI is also associated in this study. The study showed that high sensitive-C-reactive protein has higher association with acute myocardial infarction. Top Keywords High Sensitive C, Case-Control Study, Reactive Protein, Biomarker. Top |