Analysis of Serum Il-6 and CRP Levels among Autoimmune and Non-Autoimmune Hypothyroid Patients Al-Hindawi Sahar H. A.* Department of Basic Science, College of Dentistry, University of Baghdad, Baghdad, Iraq *Corresponding author: Sahar H. A. Al-Hindawi, email: saharhashim10@yahoo.com
Online published on 30 April, 2019. Abstract Hashimoto Thyroiditis (HT) is the most common autoimmune thyroid disease and the commonest cause of hypothyroidism. C-reactive protein (CRP) is synthesized in hepatocyte in response to autoimmune disorders; strongly induced by IL-6. This study aimed to estimate serum IL-6 and CRP levels in autoimmune and non-autoimmune hypothyroidism. The present study included 60 Iraqi female hypothyroid patients divided to 30 autoimmune and 30 non-autoimmune, with age ranged between 24–50 years and 30 healthy controls with age ranged between 27–52 years. Serum samples were collected from study groups. The levels of thyroid hormones (TSH, T4 and T3) were determined by using automated Chemiluminescence Immunoassay (CLIA) analysis system. Detection the levels of thyroid peroxidase antibody (TPO-Ab), thyroglobulin antibody (Tg-Ab) and Interluekin-6 by enzyme linked immunosorbent assay (ELISA) kits. While latex agglutination slide test used for determination the presence of serum CRP. The current results revealed that serum TSH, TPO-Ab, Tg-Ab, IL-6 levels and CRP positive ratio are increased significantly (P<0.01) in autoimmune hypothyroid group as compared with non-autoimmune hypothyroid group and control group. But there are no significant differences (p>0.05) between non-autoimmune hypothyroid patient and control in the level of TSH, T4, T3, TPO-Ab, Tg-Ab, IL-6. Only the positive ratio of CRP is elevated significantly than ratio in control. This study showed significant increase (P<0.01) in IL-6 level and CRP positive ratio in autoimmune hypothyroidism, that indicates to the effect of autoimmune thyroid disease on inflammatory markers IL-6 and CRP in the serum; and increase CRP positive ratio in non-autoimmune hypothyroidism suggested the alteration in the levels of inflammatory marker has been independent from etiology of thyroid disease. Top Keywords Autoimmune hypothyroidism, non-autoimmune hypothyroidism, IL-6, CRP. Top |