The Effect Insulin Therapy and Metformin on Osteoporosis in Diabetic Post-Menopausal Iraqi Women Roomi Ali B.1,*, AL-Salih Raid M. H.2, Ali Saher. A.2 1College of Health and Medical Technology, University of Al-Ayen, Iraq 2Chemistry Department, College of Science, University of Thi-Qar, Iraq *Corresponding author: Ali B. Roomi, E-mail: dr.ali_bader@alayen.edu.iqimproving
Online published on 30 April, 2019. Abstract The aim of this study is to evaluate the effects of insulin therapy and metformin on osteoporosis (OP) in diabetic post-menopausal women. In this study, 200 individuals, aged (50–73) year. Control and patients were divided to four groups, each group containing 50 patients. Group (CG) were healthy post-menopausal, group (OP) were post-menopausal with OP, group (T2D insulin) were post-menopausal with diabetic and treated insulin once daily and group (T2D-metformin) were post-menopausal with diabetic and treated metformin (500 mg) twice daily. The results revealed that fasting blood glucose (F.B.G), hemostatic model assessment-insulin resistance (HOMO-IR), and bone mineral density (BMD) demonstrated a significant different in (T2D-insulin and T2D-metformin) group comparison with (OP) group. Serum insulin demonstrated a significant increase in (T2D-insulin) group comparison with (OP) group, While a significant reduce in (T2D-metfomin) group comparison with (OP) group. Whereas, the osteocalcin (OC) and carboxy-terminal telopeptides of type I collagen (CTXI) was a significant reduce in (T2D-insulin and T2D-metformin) group comparison with (OP) group. The final concluded that insulin therapy increases bone turnover biomarkers more than metformin therapy. Top Keywords Bone mineral density, Osteoporosis, Post-menopausal, Insulin therapy, Metformin. Top |