Relation between ArV and birth Defects Hiremath Prabhuswami1,*, Patange R P2, Salunkhe J A3, Mohite Vaishali R.4, Naregal Prakash5, Pawar Ajit6 1Lecturer, Krishna Institute of Nursing Sciences, Karad 2Professor and Head, Department of OBG, Krishna Institute of Medical Sciences Deemed University, Karad 3Professor, Krishna Institute of Nursing Sciences, Karad 4Dean and Principal, Krishna Institute of Nursing Sciences, Karad 5Lecturer, Krishna Institute of Nursing Sciences, Karad 6Clinical Instructors, Krishna Institute of Nursing Sciences, Karad *Corresponding Author: Mr. Prabhuswami Hiremath, Krishna Institute of Nursing Sciences, Karad. Phone: 9665620425, Email: prabhuispn@gmail.com
Online published on 4 June, 2019. Abstract Background Two components are considered in deciding the adverse effect on fetal development in pregnant mother with HIV infection. One, effect of HIV infection on fetus and second, effect of antiretroviral treatment (ARV). The major benefit of antiretroviral treatment (ARV) during pregnancy is prevention of mother to child transmission (MTCT) of HIV infection. The combination of zidovudine and lamivudine and lopinavir/ritonavir is one of the most used ART regimens for prevention of mother-to-child-transmission. At the same time there are concern related to its effect on adverse outcome of birth outcome. There is no clear supporting data but results shows conflicting Conclusion on effect of antiretroviral treatment (ARV). Methodology hospital based prospective study was carried out at tertiary care centre, Krishna Hospital, Karad. Inclusive criteria was, Mothers who are diagnosed to have congenital birth defected fetus through antenatal examinations, delivered baby with diagnoses of congenital malformation, congenital malformed admitted neonates at Tertiary care hospital or came for reference services. Results Total 75136 babies were observed in pediatric outpatient department, 4092 babies in pediatric ward and 774 patients in Neonatal Intensive Care Unit. Total, 283 mothers were identified with birth defect. Among these, only 3 (1.1%) mothers gave information that they used ARV during pregnancy. Conclusion At the moment, few studies are available to determine the role of these drugs alone or associated with other ART in inducing birth defects31. Further in depth research is required in this aspect. Top Keywords Birth defects, Anti retroviral (ARV) therapy, relation. Top |