The Incidence and Prevalence of Virulence Factors of Vaginal candidiasis in Pregnant Women with Diabetes Mellitus Rani T Sandhya1,*, Srikumar R.2, Reddy E. Prabhakar3, Kumar Naveen4 1Research Scholar, Department of Microbiology, Sri Lakshmi Narayana Institute of Medical Sciences, Affiliated to Bharath Institute of Higher Education, Pondicherry, India 2Research Associate, Centre for Research, Sri Lakshmi Narayana Institute of Medical Sciences, Affiliated to Bharath Institute of Higher Education, Pondicherry, India 3Professor of Biochemistry, Sri Lakshmi Narayana Institute of Medical Sciences, Affiliated to Bharath Institute of Higher Education, Pondicherry, India 4Research Scholar, Department of Microbiology, Sri Lakshmi Narayana Institute of Medical Sciences, Affiliated to Bharath Institute of Higher Education, Pondicherry, India *Corresponding Author: Sandhya Rani. T, Research Scholar, Department of Microbiology, Sri Lakshmi Narayana Institute of Medical Sciences, Pondicherry, India-605502, Phone: 9581243317, Email: sandhya.micro86@gmail.com
Online published on 4 June, 2019. Abstract Background and Purpose Candida species are act as commensals, in antenatal women developed vaginal discharge which can lead to pregnancy difficulties like abortions, premature birth and other predisposing factors such as use of broad spectrum antibiotics, oral contraceptive pills and HIV/AIDS. The present study was aimed to the incidence and prevalence of virulence factors of vaginal Candidiasis in pregnant women with diabetes mellitus. Materials and Method Seventy five high vaginal swabs were collected from pregnant woman with symptoms of vaginal infection. These samples were tested by microscopical examination and culture on Sabouraud Dextrose agar to identified Phenotypic and Virulence factors of Candidia species Results Thirty five Candida species were isolated, 66% non-albicans Candida species isolated, while Candida albicans were isolated 34% from total positive sample. Non-albicans Candida species were the predominant pathogens isolated. Biofilm production was shown by (88.5%) and phospholipase activity was given by (89%). Conclusion Nonalbicans Candida spp. increased production of virulence factors in VVC cases. Its isolation from clinical specimen do not ignored as nonpathogenic isolates or contaminant. Biofilm formation and other virulence markers should be routinely screened for vaginal Candidiasis during pregnancy with diabetes. Top Keywords Candidiasis, Vulvar erythema, Biofilm and Phopholipase. Top |