Hepatoprotective Effect of nigella Sativa Seed Extract against Isoniazid and rifampacin Induced Hepatotoxicity Shreelakshmidevi S1,5, Jaikumar S2, Abilash SC3,5, Pammy S4 1Department of Pharmacology, Shri Sathya Sai Medical College & Research Institute, Sri Balaji Vidyapeeth (DU), Chennai, Tamil Nadu, India 2Department of Pharmacology, Sri Lakshmi Narayana Institute of Medical Science Medical College & Hospital, BIHER 3Department of Pathology, Shri Sathya Sai Medical College & Research Institute, Sri Balaji Vidyapeeth(DU), Chennai, Tamil Nadu, India 4Department of Pathology, Sri Lakshmi Narayana Institute of Medical Science Medical College & Hospital, BIHER 5Research Scholar, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India Online published on 4 June, 2019. Abstract Background Current century with advanced medical care still holds Tuberculosis as a prevalent condition around the world. The context to default is the adverse effects faced by patients taking anti-tubercular drugs. The most perilous among the adverse effect is hepatotoxicity and can be ameliorated by the effect of Nigella Sativa seeds. Objectives To study the hepatoprotective role of Nigella Sativa seed extract against Isoniazid and Rifampicin induced hepatotoxicity. Materials & Method The animals were divided into three groups with six animals in each group. Group I served as normal control, Group II served as positive control and received Isoniazid and Rifampicin for 10days. Group III received Isoniazid and Rifampicin with Nigella Sativa seed extract 900mg/kg was given for 10days. Blood samples where sent for AST, ALP, ALT analysis and the liver tissue for histopathology studies. Results Table 2 showed decrease in AST, APL, and ALT values in group III when compared with group II. Histopathology showed reduced hepatotoxic changes in group III when compared with group II. Conclusion The hepatoprotective property of Nigella Sativa seed extract will be a new path for safer and effective Tubercular therapy in developed and developing countries. Top Keywords Tuberculosis, Nigella Sativa seed, Isoniazid, Rifampicin, Hepatoprotective. Top |