Protective Effect of roket Leaves (Eruca Sativa) Extract against Lead Induced Oxidative Damage in Liver and Kidney of Male rats Nawfal Ahmed Jasim1,*, Tafash Haithm T.1, Mahmood Anmar Shukr2 1Department of Physiology, College of Medicine, University of Fallujah, Iraq 2Department of pharmacology, College of Medicine, University of Fallujah, Iraq *Corresponding Author: Ahmed Jasim Nawfal, Department of Physiology, College of Medicine, University of Fallujah, Iraq, Email: dr.ahmedjasim8855@gmail.com
Online published on 4 June, 2019. Abstract This study was intended to examine the prophylactic function of ethanolic extract of Eruca sativa leaves against the toxic effects of lead acetate on liver and kidney enzymes in male of rats. 32 adult male rats 175–200 gm were randomly divided into four equal groups (8 rats/group) and were treated for 10 weeks as follows: Rats of the first group were received tap water which considered as control group, Second group T1 animals in this group administrated 2.5 mg/Kg B.W lead acetate, Third group T2 animals in this group were received 2.5 mg/Kg B.W lead acetate plus 300 mg/kg. B.W. of Eruca sativa extract, Fourth group T3 animals in this group was received 300 mg/kg. B.W. of Eruca sativa extract. Serum liver and kidney functions tests were evaluation. The results manifest that the Eruca Sativa extracts at concentration 300mg/kg B.W. improved liver and kidney functions. We accomplished that, Eruca sativa extracts may appear their protective and treatment effect against oxidative damage result from lead acetate by rising/preserve the grade of antioxidant enzymes and antioxidant molecules. The histological section showed the pathological changes in the liver and tissue in T1 group while giving Eruca Sativa extract with and without lead acetate was effective in modified these changes into semi normal, the results assert the prophylactic effect of E. sativa leaves extract against oxidative damage due to lead acetate in rats. Top Keywords Eruca sativa, Hydrogen peroxide, ALT, AST, BUN, Creatinine, liver, kidney. Top |