Indian Journal of Public Health Research & Development
Year : 2019, Volume : 10, Issue : 5
First page : ( 377) Last page : ( 382)
Print ISSN : 0976-0245. Online ISSN : 0976-5506.
Article DOI : 10.5958/0976-5506.2019.01031.3

Biochemical Study and Immunohistochemistry of breast cancer after and before radiotherapy

Mahmood Aqeel Shakir

Department of Surgery, College of Medicine, University of Baghdad

Online published on 4 June, 2019.

Abstract

Across-sectional study was conducted in medical city complex, Baghdad, Iraq and baghdad teaching hospital, oncology teaching hospital. The complete physical examination was finished to every patient during the period from October 2016 to January 2017 with age range 20–40. The study included 30 patients divided two groups the group 1 before radiotherapy (new diagnosis with malignant breast cancer), and group 2 after radiotherapy (the same group 1). The last diagnosis was established by aspiration of cysts using (FNA) and mammography. Blood samples and biopsy from breast were taken from 30 women new diagnosis of malignant breast cancer and again take blood and biopsy after radiotherapy from the same women. The result shows high significantly increase of MDA levels (p<0.01)when comparing radiotherapy group(after radiotherapy) with the malignant group(before radiotherapy). A significant change of uric acid at (p<0.05) in comparison of radiotherapy group with the malignant group (p<0.05). A significantly lower level in albumin, Urea, creatinine, and vitamin E at (p<0.05) of the malignant group in relation to radiotherapy group, while a non-significant change in Vitamin A (p>0.05) when comparing the malignant group and radiotherapy group.

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Keywords

Breast cancer, MDA, Vitamin E, A, Uric acid, Albumin, urea, creatinine.

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