Effects of Trichuris Muris Infection on Mice (Mus musculus) Intestine Istiana1,*, Ulfadhila Lulu Hasna2, Nisa Khairun2, Kurniati Rizki2, Husairi Ahmad3 1Department of Parasitology, Lambung Mangkurat University, Indonesia 2Student, Department of Anatomy, Faculty of Medicine, Lambung Mangkurat University, Indonesia 3Department of Anatomy, Faculty of Medicine, Lambung Mangkurat University, Indonesia *Corresponding Author: Istiana, Department of Parasitology, Faculty of Medicine, Lambung Mangkurat University, Indonesia, Email: dr.istiana@ulm.ac.id, oputriandini@gmail.com
Online published on 4 June, 2019. Abstract Helminth infection can influence immunopathology in human body. Changes in the length of intestine and release an increased goblet cell is one of the defense mechanisms against worm infections. In this study, we analyze effects of Trichuris muris infection towards goblet cells number and the l e n g t h o f villi and crypt intestine of mice This research was a true experimental with the posttest control group design. The subjects were 30 males mice types BALB/c which 2 months old with an average weight 20–30 grams. Samples were taken by simple random sampling. Mice divided into a control group, low-dose group and high-dose groups. All subject was observed for 30 days, and the intestine was taken for measured length of villi and crypt. Counting of goblet cells used preparation of intestine. Data analysis used one way Anova and continued by post hoc test. The result show that crypt and villi on large and small intestine will be longer in mice with Trichuris muris infection. The average value of the goblet cells number in the control group, low-dose and high dose increased by higher dose worm eggs and had the value (p =< 0.05). Trichuris muris infection has influenced t h e l e n g t h o f villi and crypt intestine and the number of goblet cells in mice (Mus musculus). Top Keywords Trichuris muris, length of intestinum, goblet cells number. Top |