Correlation between DMF-T/def-t and the Secretion of Salivary HBD-1 in carious and non-carious Group of children Indrawati Retno1,*, Setiabudi Hendrik1, Luthfi Muhammad1, Nabella Tamima Izzat3, Aulia Dien Nisa3, Tantiana1, Pradopo Seno2 1Staff of Lecturer in Department of Oral Biology, Universitas Airlangga, Surabaya, Indonesia 2Staff of Lecturer in Departement of Pediatric Dentistry, Universitas Airlangga, Surabaya, Indonesia 3Undergraduated Student, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia *Corresponding Author: Retno Indrawati, Faculty of Dental Medicine, Universitas Airlangga. Surabaya, Indonesia, Mayjen Prof. Dr. Moestopo 47, Surabaya, Indonesia, 60132; Email: retnoindrawati@fkg.unair.ac.id
Online published on 4 June, 2019. Abstract Background DMF-T/deft (Decay Missing Filled Teeth) is an index for assessing dental and oral health status, in this case, dental caries. Dental caries is a multifactorial disease with factors namely teeth and saliva, microorganisms, dietary, and time that affecting each other. Human Beta Defensins-1 (HBD-1) is an Antimicrobial Peptides (AMPs) that has a role as an adaptive immune system in oral health, is a factor that affects the susceptibility and development of dental caries that exhibits activity in Streptococcus mutans bacteria. Objective To prove the relationship between DMF-T/deft and the levels of HBD-1 saliva secretion in the carious and non-carious groups of children. Method This study was an observational analytic with cross-sectional study design, with the division of 3 groups namely; group 1 (DMF-T/deft = 0, caries-free), group 2 (DMF-T/deft = 1–3, low caries), and group 3 (DMF-T/deft > 6, high caries). Result DMF-T/deft index (1, 000) obtained HBD-1 concentration (−0.451). Low DMF-T/deft index has high HBD-1 concentration, whereas high DMF-T/deft index has low HBD-1 concentration. The value of p < (0.05) showed there was a significant correlation between the DMF-T/deft index with salivary HBD-1 concentrations. Conclusion There was a relationship between DMF-T/deft and the level of HBD-1 saliva secretion in the carious and non-carious groups of children. Top Keywords DMF-T/def-t, Saliva, Streptococcus mutans, Dental Caries, Human Beta Defensins-1. Top |