Anti-inflammatory and inflammatory as Diagnostic Markers in Type2 Diabetes Mellitus Mohammed Haithem R.1,*, Al-Obaidi Zaid Mahdi Jaber2 1MSc. Department of Clinical Pharmacy in University of Kerbala. Iraq 2MSc. Department of Pharmaceutical Chemistry in University of Kerbala, Iraq *Corresponding author: Haithem R. Mohammed, E-mail: haithem.rauf@gmail.com
Online published on 4 June, 2019. Abstract The diabetes mellitus is more globally chronic metabolic disorder that characterized by chronic hyperglycemia result from insulin deficiency and/or resistance to the action of insulin. this study is design to evaluate the serum level of TNFα and adiponectin in type2 diabetic patients and also to discriminate the diabetic patient from the control.present study included 80 individuals divided to 40 type 2 diabetic patient and 40 healthy control subjects the blood samples were collected from all participants to made the laboratory analysis. Results show that The gender, age and BMI was matched between patients and control subjects. The serum level of adiponectin was significantly lower in diabetic patients (p<0.05). The serum level of TNFα was significantly higher in diabetic patients in compared to controls (p<0.05). The lipid profile was significantly higher in diabetic patients in compared to controls. The ROC curve analysis show that the adiponectin and TNF have high sensitivity and specificity for diagnosis the diabetic patients, the optimal cut point was ≤15.3 and >40 for adiponectin and TNF respectively. Conclusion The serum level of adiponectin decreased significantly in type2 diabetic patients and also the serum level of TNF was increased significantly in T2DM patients.the adiponectin and TNF can used to distinguished the T2DM patients. The deficiency of adiponectin regareded as a risk for developing T2DM. Top Keywords adiponectin, TNFα, T2DM, increased significantly. Top |