Role of Vitamin D3 in Breast Cancer Development among Iraqi Patients Abdul-Khaliq Ala'a1, Al-Haidary Batool A.2, Abbas Nahida R.1 1Technical Institute, Al-Mansour, Iraq 2Middle Technical University, Iraq Online published on 4 June, 2019. Abstract Breast cancer (BCa) still a big problem for women and many factors play a crucial role in its development. The goal of this investigation to shed light on the role of Vitamin D3, as well as Leptin in Breast Cancer development. One hundred females complaining from breast tumor has been enrolled in this study. Histopathological study showed that 75 of them had Breast Cancer and the remaining had benign tumors. Enzyme linked Immunosorbent Assay was applied for estimation of Leptin Vitamin D3 and Ca 15.3 levels in the sera of those women and the results were compared with those for 50 apparently healthy volunteers control group. This study revealed that most breast masses occur within left breast (70%) and majority of them were ductal (49.3%) type. Additionally, the risk age for BCa development was noticed among age 40–49 years with a frequency of 40%. Moreover, it was observed that there was significant difference in the mean of Vitamin D3among BCa (17.46±10.94 ng/ml) in comparison with healthy controls (21.17±8.73 ng/ml) (<0.05). Mean of tumor marker Ca 15.3 concentration was elevated in highly significant manner among BCa sera (30.18±38.81 ng/ml) in comparison with disease control group (i.e. Benign tumor cases) (14.30±7.46 ng/ml) and healthy control group (14.64±6.73 ng/ml) (P < 0.001). According to the above results it could be concluded that Vitamin D3 can be a good therapeutic agent to prevent development of BCa particularly among women after menopause age. Tumor marker Ca15.3 was reckoned as a best indicator for BCa. Top Keywords Vitamin D3, Breast cancer, Ca 15.3. Top |