Interleukin-12A (Rs583911) Polymorphism in Pediatric Patients with Acute Lymphoblastic Leukemia In Iraq Kadhim Manal M.1,*, Abd-Alraoof Tabarek S.1 1Department of Medical Microbiology, College of Medicine, Al-Qadisiya University, Diwaniyah, Iraq *Corresponding author: Manal M. Kadhim, E-mail: manal.kadhim@qu.edu.iq
Online published on 4 June, 2019. Abstract Acute Lymphoblastic Leukemia is a malignant disorder of lymphoid progenitor cells and the most common type of malignant neoplasms in children. This study was conducted toevaluate the role of IL-12A (rs583911) gene polymorphism in the pediatric acute lymphoblastic leukemia. Evaluated and investigated the single nucleotide polymorphisms of IL-12A (rs583911) gene in 120 subjects. Sixty were Acute Lymphoblastic Leukemia patients while others were apparently healthy individuals used as a controls. The frequencies of genotype AA was significantly more frequent in study group than in control groups, 26.7% versus 10.0%, variant allele A was more frequent in study than in control group, 43.35% versus 56.7%. AA genotype is mainly expressed among Acute Lymphoblastic Leukemia patients and it may considered as a risk factor for ALL. Top Keywords Acute Lymphoblastic Leukemia, IL-12A (rs583911), Allele, Genotype, AS-PCR. Top |