Study the Relationship between TEX101 Protein, Inhibin B and Testosterone Hormone in Azoospermia and Severe Oligospermia in Infertile Patients Hammood Samah A.1,*, AL-Sallami Alaauldeen S.1, Al-Khafaji Saleh M.2 1Department of Biology-College of Science, University of Kufa 2Department of Anatomy & Histology-College of Medicine, University of Kufa *Corresponding author: Samah A. Hammood, E-mail: samah.alobaidi@uokufa.edu.iq
Online published on 4 June, 2019. Abstract Background Infertility remains a global health challenge with devastating psycho-social consequences in many Iraqi communities and an underlying long-term risk for separation of couples. Therefore, this study was aimed to determine the effect of a biochemical marker; Testis-expressed sequence 101 protein(TEX101) and relation with Inhibin hormone and testosterone on infertile couples of (Middle Euphrates center) in Iraqi population. Method The study involved analysis of semen parameters in accordance with the criteria set by World Health Organization in the Fertility Centre in Al-Sadder Teaching Hospital in Al-Najaf/Iraq and postgraduate Laboratory at Biology Department/College of Science, University of Kufa during the period from 1st, April 2018 to 30th, August 2018 of (53)Azoospermia infertile patients samples, (50) severeoligospermia samples and (50) samples of fertile subjects (control group). The biochemical marker was achieved by ELISA method. Results The result of current study of biochemical markers showed decrease (P<0.05) in TEX101, Testosterone hormone and inhibin B in azoospermia. Also, the study showed that TEX101, Inhibin B and Testosterone were positively associated with sperm concentration, sperm motility and normal sperm morphology. Conclusion TEX101 positively related with Inhibin B and testosterone hormone and semen normal parameters. Top Keywords TEX101, Inhibin B, Testosterone, Azoospermia, infertility. Top |