Evaluation of the Diagnostic Accuracy of Transient Elastogaraphy and Apri Score in Chronic Hepatitis B (CHB) in a Sample of Iraqi Patients Shammaa Ali Sameer AL1,*, Mehdi Mohammed Abdulla2, Akaishee Raghad Jawad Al3 1Al Nahrain University, College of Medicine, Iraq 2Mustansiriya Medical College, Mustansiriya University, Iraq 3Consultant Gastroenterologist & Hepatologist in Gastroenterology & Hepatology Teaching Hospital-Baghdad, Iraq *Corresponding author: Ali Sameer AL Shammaa, E mail1: dralisameer80@colmed-alnahrain.edu.iq
Online published on 4 June, 2019. Abstract Background Hepatitis B is a global chronic disease caused by the hepatitis B virus. Development of liver cirrhosis is one of the most important and serious complication of this infection. Aim of the study was to Assess the diagnostic accuracy of transient elastogarphy and AST to platelet ratio index (APRI) score in detecting the degree of liver fibrosis in chronic hepatitis B (CHB) patients, with biopsy samples as a reference standard. Method Thirty-seven patients diagnosed as CHB were recruited and the stage of fibrosis was determined by biopsy. The diagnostic accuracy of FibroScan (Echosens, Paris, France) and APRI was evaluated based on the conformity of the results from these tests with those of biopsies. An expert operator performed all measurements. Metavir score was used to assess the degree for liver fibrosis. Results The Metavir score for liver biopsies were (F0-F1 N=22, F2 N=12, F3 N=2, and F4=1), while the score assessment by Fibroscan were (F0-F1 N=24, F2 N=10, F3 N=1, and F4=2). There was a significant association between the two groups by the level of assessment method of liver fibrosis (P<0.05). The mean score for APRI, for patients with early degree of liver fibrosis (Metavir Score liver histology F0-F1) (N=22), was 0.58 (SD= 0.417), while those with advanced fibrosis (F3) their mean APRI core was 0.49. Comparing the mean of APRI score results with those of liver histology (ANOVA test), there was no significant association between the two groups (P>0.005). Conclusion Transient elastogarphy (FibroScan) has a reliable results in assessing the degree of liver fibrosis in CHB patients. APRI score did not show a significant association with degree of fibrosis in CHB patients. Top Keywords Hepatitis, liver cirrhosis, elastography, biopsy, APRI. Top |