Antioxidants and Antibodies in Structural Thyroid Diseases Javalgi Anita P1,*, Yelikar B R2, Das Kusal3 1PhD Scholar, Department of Pathology, BLDE University's Shri B M Patil Medical College, Vijayapura, Karnataka 2Prof & Head, Department of Pathology, BLDE University's Shri B M Patil Medical College, Vijayapura, Karnataka 3Professor, Department of Pathology, BLDE University's Shri B M Patil Medical College, Vijayapura, Karnataka *Corresponding Author: Dr Anita P Javalgi, Department of Pathology BLDE University's Shri B M Patil Medical College, Vijayapura, Karnataka, Phone: 09590196666, Email: anitajawalgi@gmail.com
Online published on 19 August, 2019. Abstract Thyroid nodules are a very frequent finding, and their prevalence steadily increases with age. Routinely clinical factors such as age, gender, and radiation history are meaningful for predicting thyroid nodules. There are few studies exploring the association of serum indexes of thyroid hormones or autoantibodies with the risk of thyroid nodules. Hence present study was undertaken with following objectives. To measure the serum markers of FT3, FT4, TSH, anti TPO antibody, anti-thyroglobulin antibody and role of Vitamin E and vitamin C antioxidants in relation with thyroid serum markers in various thyroid diseases. Correlation of these serum markers with cytological diagnosis was done. Serum analysis of thyroid hormones, autoantibodies level and FNAC was done with patients having thyroid swelling. It was noted in present study that prevalence of positive serum autoantibodies displays geographical heterogeneity, unrelated to goitre prevalence. Autoantibodies levels are raised in autoimmune thyroid diseases and in few variants of thyroid malignancy. And it was also observed anti-Oxidants (vitamin e and vitamin c) levels were variable in thyroid disorders. To conclude autoantibodies are markedly raised in thyroiditis condition and the incidence of autoimmune thyroiditis is increasing in iodine sufficient as well as iodine deficient geographical areas. In present study it was also observed that autoantibodies levels were raised in papillary carcinoma thyroid indicating role of anti-TPO and anti-TG in etiopathogenesis. Antioxidants levels were variable and low in most of thyroid diseases suggesting its role in etiopathogenesis. Top Keywords Auto-antibodies, antioxidants, goitre, papillary carcinoma. Top |