The Relation between Homocysteine, Oxidative Stress and Atherosclerosis Disease Hassan Ekhlas Abdallah* Wafaa Sh. Al-Zuhairi, Alzahraa Ibrahim Abdulmajeed, Department of Chemistry, College of Science, University of Diyala, Baquba, Diyala, Iraq *Corresponding Author: Ekhlas Abdallah Hassan, Wafaa Sh. Al-Zuhairi, Alzahraa Ibrahim Abdulmajeed Department of Chemistry, College of Science, University of Diyala, Baquba, Diyala, Iraq Email: ekhlasbiochemistry@gmail.com
Online published on 19 August, 2019. Abstract Homocysteine(Hcy) may promote atherogenesis through oxidativestress. Malondialdehyde (MDA), which produced through peroxidation of lipid. It is widely used in estimating the oxidative stress. We aimed to evaluate the serum Hcy levelsand serum MAD in atherosclerosis patients and to find whether these variables are associated with the severity of atherosclerosis disease. Sixty patients diagnosed with atherosclerosis diseases were included in our study. Patients were divided to three groups(Low risk= 1.0, moderate risk = 3.55, and high risk= > 6.15) according to the value of atherogenic index. Fifteen healthy individual, as control group. Serum MDA is estimated by methods of Benge (1978). Hcy were quantitatively determined in patients and control subjects by ELISA test. The receiver operator curve (ROC) analysis of the forthcoming variations revealed the descending order of (Hcy = 0.959; MAD = 0.832;TC = 0.609; LDL = 0.594;and Tri = 0.502) that showed significant variation. The rest of parameters (uric acid, HDL and albumine) failed to occupy a significant ROC area. In our study, we found serum each Hcy and MAD was significantly increased in patients than control; it was gradually increased with increase atherogenic index, affected by the severity of disease, and significantly increases in third group than first group of patients. Person linear correlation revealed a significant positive linear correlation with serum Hcy and MAD and increased risk factor of atherosclerosis disease in the three progressed groups of patients. In summary, there is a significant relation between Hcy levels, MDA, and atherosclerosis diseases. This relationship could cause early development of atherosclerosis diseases even in males. So we suggest that Hcy and MAD might be taken into consideration through the evaluation of atherosclerosis patients Top Keywords Atherosclerosis, homocysteine, malondialdehyde, oxidative stress. Top |