Study the Effect of Lycium barbarum Polysaccharide on Bone and Thyroid Gland in Hyperlipidemic Healthy Male Albino Rats Alsalame Heba A. Abd-Alsalam* College of Education for Pure Science, University of Kerbala, Iraq *Corresponding Author: Heba A. Abd-Alsalam Alsalame, College of Education for Pure Science, University of Kerbala, Iraq, Email: hebaalsalame82@gmail.com
Online published on 19 August, 2019. Abstract The aim of the study was to determine the protective role of Lycium barbarum Polysaccharide against the development of osteoporosis and hypothyroidism induced by high cholesterol diet in male albino rats, 45 male albino rats were grouped into three sets. The first group (G1) was fed with normal diet and considered as a control group. The second group (G2) was fed 2% cholesterol-enriched diet for three months to induction of hypercholesterolemia, while The third group (G3) was fed 2% cholesterol-enriched diet +100mg/kg of Lycium barbarum Polysaccharide (LBP). Blood samples were withdrawn after starvation of the animals at night, after the end of three months, 5 ml of blood was withdrawn from the heart to measure the following parameters: concentration of total cholesterol (TC), High density lipoprotein (HDL), Low density lipoprotein (LDL), Very low density lipoprotein (VLDL), Triglyceride (TAG), Alkaline Phosphatase (ALP), phosphorus (p+), Calcium (Ca+), Parathyroid Hormone (PTH), Thyronine (T3), Thyroxin (T4) and Thyroid stimulating hormone Hormons(TSH). Rats in G2 had significantly greater levels of TC, TAG, LDL, and VLDL compared to G1, while the picture was an opposite direction in the levels of HDL. G2 rats had significantly greater levels of PTH, calcium and phosphorus, while ALP levels were significantly reduced compared to that observed in G1 rats. Levels of thyroid hormones (T3, and T4) were significantly decreased, while the TSH levels were significantly increased in the G2 rats compared to that of G1 rats. Rats in group 3 did not reveal any significant changes in all measured biomarkers comparing to that values measured in G1. It is concluded from the present study that hyperlipidemia increases osteoporosis risk and causes thyroid dysfunctions and confirms the protective role of the Lycium barbarum Polysaccharide against osteoporosis risk and maintain thyroid dysfunctions in male albino rats. Top Keywords Lycium barbarum, Polysaccharide, bone, thyroid gland, male, albino rats. Top |