Evaluation of Immunostimulant and Chemprotective Activity of Chicoreus Ramosus against Cisplatin Induced Toxicity in Balb/C Mice Bindhu J.1,*, Das Arunava2 1Research Associate cum Assistant Professor, Molecular Diagnostics and Bacterial Pathogenomics Research Laboratory Department of Biotechnology, Bannari Amman Institute Technology, Sathyamangalam, Erode District, Tamil Nadu, India 2Associate Professor, Molecular Diagnostics and Bacterial Pathogenomics Research Laboratory Department of Biotechnology, Bannari Amman Institute Technology, Sathyamangalam, Erode District, Tamil Nadu, India *Corresponding author: Mrs. J. Bindhu Research Associate cum Assistant Professor Molecular Diagnostics and Bacterial Pathogenomics Research Laboratory, Department of Biotechnology, Bannari Amman Institute Technology, Sathyamangalam-638401, Erode District Tamil Nadu, India, E.mail Id: bindhu@bitsathy.ac.in
Online published on 13 November, 2019. Abstract Traditional plant medicines are used for a range of cancer displays. The Chicoreus ramosus is an enormously proteinaceous gastropod for human consumption. In this research evaluation of chemoprotective activities Chicoreus ramosus (CR) in cisplatin-triggered immunosuppressed mice was studied. Cisplatin (100mg/kg, intraperitoneally [IP]) brought on immunosuppressed mice changed into treated with Chicoreus ramosus (150 mg/dose/animal/IP) for a duration of 10-day. The influence of the extract on lymphoid organ weight, bone marrow cellularity, alpha esterase hobby and on enzyme degrees such as SGOT, SGPT, Urea, Creatinine changed into estimated to choose out the chemoprotective impact of CR. Administration of CR in cisplatin treated mice, found to enhance bone marrow cellularity and α-esterase exquisite cells, which were appreciably decreased in cisplatin best handled control animals indicates that cisplatin brought on myelosuppression changed into reversed or inhibited by CR management probably via its chemoprotective activity. Cisplatin bounds to DNA and reasons damages ensuing in chromosome breaks, micronucleus formation and cell loss of life. CR contains several center-chain aliphatic alcohols, aldehydes and ketones, which can be believed to be the quit yields of fatty acids. Administration of CR in cisplatin handled mice, boosts the bone marrow cellularity and α-esterase advantageous cells, which have been notably reduced in cisplatin best indicates that cisplatin caused myelosuppression was reversed or inhibited via Chicoreus ramosus. Top Keywords Chicoreus ramosus, Chemoprotective, Cisplatin; Alpha Esterase, SGOT, SGPT. Top |