The Role of Zinc Sulfate in Reducing Levels of TNF-α, IL-1β and iL-6 in Multi Basiler Leprosy Patients Kurnianto Joko1,*, Sulchan Moh.2, Kabulrakhman2, Hertanto WS2, Suharyo HS2, Prasetyowati2 1Doctoral Program Faculty of Medicine, Diponegoro University, Semarang, Indonesia 2Faculty of Medicine, Diponegoro University, Semarang, Indonesia *Corresponding Author: Joko Kurnianto, Doctoral Program Faculty of Medicine, Diponegoro University, Semarang, Indonesia Email: joko.kurnianto@gmail.com
Online published on 13 November, 2019. Abstract Background The role of Zinc as an anti-oxidant and anti-inflammatory has been proven and this substance is relatively cheap and easily obtained by the community. This research aims at analyzing the effect of 40 mg/day of Zinc sulfate for 12 weeks on zinc and pro-inflammatory cytokines TNF-α, IL-1β and IL-6 in MB-type leprosy patients. Method The study design used randomized pretest-posttest control group design, the study subjects were MB patients with 121 patients who did not experience leprosy reactions, 31 subjects were analyzed as a supplementation group, and 31 patients as a control group. Measuring serum zinc levels using method Atomic Absorption Spectrophotometer (AAS), the levels of TNF-α, IL-1β and IL-6 using method of ELISA, statistical analysis using independent t-test, paired test, Mann Whitney and Wilcoxon sign rank test, Results Zinc sulfate supplementation of 40 mg/day for 12 weeks in MB-type leprosy patients controlling the decrease in zinc levels of 1.22 pg/dL was higher than leprosy patients who did not receive Zinc sulfate supplementation, significantly reducing IL-1β cytokine levels (p: 0.032), but significantly reduced cytokine levels, TNF-α (p: 0.063) and IL-6 (p: 0.389). Conclusion Zinc sulfate supplementation of 40 mg/day for 12 weeks in MB type leprosy patients controlled the decrease in serum Zinc levels, and reduced levels of pro-inflammatory cytokines IL-1β. Top Keywords Zinc supplementation, TNF-α, IL-1β, IL-6, MB, leprossy. Top |