Role of Betatrophin and irisin on Diabetes Mellitus Type1 Management (Experimental Study) Majeed Maysaa J.1, Al-Sharifi Zainab A. Razak1,*, ibrahim Shifaa Jameel1 1Department of Biochemistry, Collage of Medicine, University of Baghdad, Baghdad, Iraq *Corresponding Author: Marwah Safaa Ali, Department of Oral and Maxillofacial Surgery, College of Dentistry, University of Kufa, Iraq Phone: 07702842613 Email: marwasafa90@gmail.com
Online published on 13 November, 2019. Abstract Background Type 1 diabetes occurred when immune system destroys cells of pancreas called beta cells, usually treated with insulin and was advised to get regular physical activity. Aim of Study Evaluate irisin hormone as represented the exercise hormone in the treatment of diabetes type1rats in comparison with betatrophin hormone. Material and Method Twenty three rats were included in this study, five of them was considered as control group, while the rest injected with a single dose of alloxan 0.1mg/g, in order to develop diabetes type1, six of them were dead. Six of inducible diabetes type1 rats were treated with betatrophin. The other six rats were treated with irisin. Spss version 18 was used in the expiations of statistical methods of the research. Results After diabetes type1 induction, diabetic rats type1 groups showed higher blood sugar and serum irisin and lower serum insulin and btatrophin level than control group with p<0.05. Diabetic rats’ type1 with Betatrophin injection showed significant lower blood sugar and significant higher serum insulin level with when compared with Diabetic rats type1after irisin injection treatment. Conclusion Betatrophin can hold a hope for diabetes type1 control more than irisin Top Keywords Diabetes mellitus, irisin, betatrophin and rats. Top |