Assessment of Vascular Endothelial Growth Factor in the iraqi Patients with Ovarian cancer and its correlation with Angiogenesis Mahbool Mohammed Sharem1,*, Ali Abdul Hussein Razzaq1, Alafloogee Jabbar Fadeel Mahdi2 1M.B.CH.B.DM Internal Medicine 2M.B. Ch. B. Dm of Medicine C.A.B.M.F.I.C.M, Al Hussain Medical City, Iraq *Corresponding Author: Mohammed Sharem Mahbool, M.B.CH.B.DM Internal Medicine, Al Hussain Medical City, Iraq, Phone: 009647804034858, Email: mohammad7058taii@gmail.com
Online published on 13 November, 2019. Abstract Vascular endothelial growth factor (VEGF) is an important in the formation of new blood vessels which is also known as angiogenesis. It is important in restoring oxygen supply to tissues in case of tissue hypoxic a condition which is normally occurs in the cancer/tumor cells. The aim of the study was to evaluate the correlation between the serum VEGF and angiogenesis in the ovarian cancer patients. This study included 20 ovarian cancer patients enrolled to the Al Hussain medical city hospital in January 2018 to January 2019. The ovarian cancer was detected by the ultrasonography. The enrolled patients are between the age group between 40-50years. The patients with the diabetes, cardiovascular disease were excluded from this study. The fasting blood was collected after getting participant oral consent. The samples were subjected to serum isolation and it was used to evaluate the serum VEGF level by commercially available kits. In the present study, the malignant tumor patients showed significant high levels of serum VEGF in the pre-surgery stage than the benign tumor patients in the same stage. VEGF can be one of the factors which promote the malignancy in the tumor. Top Keywords Vascular endothelial growth factor, Angiogenesis, Surgery, Malignant tumor. Top |