Impact of Thyroid Dysfunction on control of Diabetes Mellitus Al-Mudhafar Zahraa Abdulaali1,*, Ahmed Israa Nihad2, Turki Mohammed Sami2, Khudhair Safaa Ali3 1Department of Physiology, Faculty of Medicine, University of Kufa, Iraq 2Najaf Health Directorate, Ministry of Health, Iraq 3Department of Medicine, Faculty of Medicine, University of Kufa, Iraq *Corresponding Author: Zahraa Abdulaali Al-Mudhafar, Assistant Prof., Department of Physiology, Faculty of Medicine, University of Kufa, Najaf, Iraq, Phone: 00-964-7803179880, Email: drzehraa65@gmail.com
Online published on 13 November, 2019. Abstract Background Diabetes mellitus (DM) refers to a group of common metabolic disorders that share the phenotype of hyperglycemia. There are two broad categories of DM, designated type 1 and type 2. Thyroid hormones affect glucose metabolism via several mechanisms. Thyroid disorders and DM are the two most common endocrine diseases reported in clinical practice and each can influence the other. During hyperthyroidism, the half-life of insulin is reduced together with increase hepatic glucose production and increase in glucose gut absorption. In hypothyroidism, reduced glucose absorption from gastrointestinal tract is accompanied by diminished hepatic glucose Production. Aim of the Study To assess effect of thyroid dysfunction on control of diabetes mellitus. Patient and Method This is a cross sectional study enrolled 60 patients with diabetes mellitus and thyroid disorder; 16 male (26.7%) and 44 female (73.3%) with a mean age of 47.2 ± 13.6. The patients were collected from center of diabetes and endocrine disease in Al-Najaf and Al-Manathera center during the period from April (2018) to December (2018). The effect of thyroid dysfunction on glycemic control has been evaluated using HbA1c as marker of control. Results There was a significant relationship between HbA1c and thyroid status in both hyperthyroid and hypothyroid patients. No significant difference was observed in the distribution of thyroid disorder between the two types of DM and among different age groups, but significant difference was reported between female and male diabetic patients. Conclusion Thyroid dysfunction in form of hyperthyroidism and hypothyroidism associated with poor glycemic control in diabetic patients. Top Keywords DM-Hypothyroidism-Hyperthyroidism. Top |