Effect of ChannaStriata Extract on the Expression of Tumor Necrosis Factor-α (TNF-α) in Rat Experience Periodontitis Adam Andi Mardiana1, Thahir Hasanuddin1, Achmad Harun2 1Periodontics Department, Hasanuddin University, Makassar, South Sulawesi, Indonesia 2Department of Pedodontic, Faculty of Dentistry, Hasanuddin University, Makassar, South Sulawesi, Indonesia Online published on 13 November, 2019. Abstract Chronic inflammatory processes in periodontal disease are triggered by a number of bacteria that stimulate the body's immune response, resulting in the release of inflammatory mediators namely cytokines which reduce the ability of cells to repair damaged tissue. Mechanical or anti-infective periodontal therapy is focused on eliminating the inflammatory process and stopping the development of the disease using certain ingredients. Channastriata extract has a substantial content, such as albumin, Zn, Cu, and Fe which accelerates the healing process of inflammation and tissue regeneration. This study aimed to measure the effect of Channastriataextract on inflammatory healing in Wistar rats induced by periodontitis through immunohistochemical examination on day 3 and 7 to see expression of tumor necrosis factor (TNF-α). This is an experimental study with a post-test and control group design. The sample consisted of 2 treatment groups, namely the Channastriataextract treatment group, and the negative control group. The average TNF-α expression peaked on day 3 in both the control and treatment groups but was lower in the treated group. T-testshowed a significant decrease in TNFα expression [p < 0.05] on day 7 the group used albumin as an additional treatment. In conclusion, the application of snakehead fish extract significantly reduced TNF-α expression. Top Keywords ChannaStriata extract, Periodontal pocket, Periodontitis. TNF-α expression. Top |