Effect of Moringa Leaf Extract (Moringa Oleifera) on increasing the Number of Osteoblas as a Marker of Bone Remodeling Djais Arni Irawaty1, Thahir Hasanuddin1, Hatta Muchammad2, Achmad Harun3, Sari Melyanti4 1Department of Periodontia, Faculty of Dentistry, Hasanuddin University, Makassar 2Department of Microbiology, Molecular Biology and Immunology Laboratorium, Faculty of Medical, Hasanuddin University, Makassar 3Department of Pedodontia, Hasanuddin University, Makassar 4Professional Program Students, Faculty of Dentistry, Hasanuddin University, Makassar Online published on 13 November, 2019. Abstract Introduction The process of bone remodeling will continue to occur when a balance between cell activities such as osteoblasts and osteoclasts also occurs. This process is controlled by hormones such as estrogen. Estrogen is known to increase the process of osteoblast differentiation and bone formation so that estrogen therapy is currently considered an effective therapy in preventing bone damage. The activity of estrogen hormone is similar to phytoestrogen activity). One type of phytoestrogens is quercetin. One of the plants in nature which contains the most quercetin is Moringa oleifera. Objective To determine the effect of quercetin obtained from natural ingredients namely Moringa leaf extract to increase the number of osteoblasts as a marker for bone remodeling. Literature Review Leaf extract of Moringa oleifera plant contains many flavonoids. One of the most common types of flavonoids found in Moringa plants is quercetin. Quercetin is proven to increase bone formation by suppressing osteoclast formation and activity. Quercetin also has anti-oxidant and anti inflammatory effects. Conclusion Leaf extract of Moringa oleifera plant can increase the number of osteoblasts as a marker of bone remodeling. Top Keywords Moringa leaf extract, quercetin, osteoblasts, osteoclasts, bone remodeling. Top |