Association of TNF-α with fasting glucose, insulin and insulin resistance in complete glycemic spectrum Rajendran Rajathi1, Sharma Vivek Kumar2,*, Ramesh A3, Vinod K V4,5 1Ph. D. Scholar, Department of Physiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India 2Professor and Head, Department of Physiology, Government Institute of Medical Sciences, Greater Noida, Uttar Pradesh 3Professor-Head, Department of Radiology, JIPMER 4Additional Professor, Department of Medicine, Dr Nandeesha H, JIPMER 5Associate Professor, Department of Biochemistry, JIPMER *Corresponding author: Dr. Vivek Kumar Sharma, Professor and Head, Department of physiology, Government Institute of Medical Sciences, Greater Noida, U.P-201310. Mobile: 9442529673. Email: drviveksharma@yahoo.com.
Online published on 1 November, 2018. Abstract Background The aim of the present study is to assess fasting glucose, fasting insulin, insulin resistance, and inflammation in complete glycemic spectrum and to study the association between them if any. Materials and Method Participants (30–50 years) of either gender were enrolled. Based on their family history of diabetes and glucose levels, they were grouped into normoglycemic non-first-degree relatives of diabetes, normoglycemic first degree relatives of diabetes, Prediabetes and diabetes. Fasting Glucose, Fasting insulin and Tumor necrosis α (TNF-α) concentrations were analyzed. Groups were compared using one-way ANOVA with LSD posthoc analysis. Correlation between the parameters were done using Pearson's correlation and linear regression analysis. Results We observed that fasting insulin, fasting glucose, TNF-α, and HOMA2 IR gradually increased as we moved along the glycemic spectrum from control, FDRD, prediabetes to diabetes, while HOMA2%S gradually decreased. HOMA2%B-there is an increase in FDRD as compared to controls, but it decreased in prediabetes and diabetes as compared to FDRD or controls. There was positive correlation between TNF-α and fasting glucose across the glycemic spectrum and no correlation with fasting insulin or insulin resistance. Conclusion Inflammation begins even in first degree relatives of diabetes and increases along with glucose levels along the glycemic spectrum. Top Keywords First degree relatives of diabetes, prediabetes, HOMA2%B, HOMA2%S, HOMA2IR, HOMA-IR. Top |