Phytochemical analysis and antifungal activity of Ganoderma lucidum Kumar C Naveen1, Srikumar R2, Swathi S3, Chidambaram R4, Muthukrishnan G5, Reddy E Prabhakar6 1Ph. D Scholar cum Assistant Professor, Department of Microbiology, Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry 2Research Associate, Department of Center for Research, Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry 3Tutor, Department of Microbiology, Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry 4Professor, Department of Radiology, Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry 5Scientist-C, Model Rural Health Research Unit, National Institute of Epidemiology (ICMR/DHR), Tirunelveli 6Professor cum Central Lab Head, Department of Biochemistry, Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry Online published on 9 January, 2019. Abstract Ganoderma lucidum has been used for several decades for both treatment strategy and health promotion. The manifestation of new infections, drug resistant, high costs of synthetic drugs and their side effects has led to an increase in the use of traditional medicine globally. Hence an endeavor has been made in this study to examine the antifungal activity of both ethanol and methanol extracts of G. lucidum. The phytochemical screening was done to reveal the bioactive constituents of G. lucidum. The phytochemical screening of G. lucidum revealed that the extracts contain bioactive compounds such as carbohydrates, glycosides, triterpenoids and phenolic compounds. The both extracts of G. lucidum were then subjected for the Minimum Inhibitory Concentration (MIC) determination with the help of micro-dilution bioassay. Various pathogenic organisms were selected against which the antifungal activity of the extracts were determined. The result of the antifungal activity showed that the methanolic extract of G. lucidum showed the strongest antifungal activity among the two extracts against the fungal strains. Top Keywords Ganoderma lucidum, Antifungal activity, Minimum Inhibitory Concentration. Top |