The Effect of IL-6 Expression on the Behavior of Oral Squamous Cell Carcinoma Cells (An immunohistochemical Study) Ghazi Osama M.1,*, Al-Azzawi Lehadh M.1 1Department of Oral Diagnosis, College of Dentistry, University of Baghdad, Iraq *Corresponding author: Osama M. Ghazi. Department of Oral Diagnosis, College of Dentistry, University of Baghdad, Iraq
Online published on 2 February, 2019. Abstract oral squamous cell carcinoma (OSCC) was and still constitutes a major challenge for medical researchers. Many researchers link between TNM stage, tumor grade, tumor depth of invasion, mode of invasion, perineural invasion, and lymphovascular invasion with locoregional recurrence and poor survival in-patients with OSCC and they concluded that these parameters could be used as prognosticators in this tumor. IL-6 is a multifunctional member of interleukin 6 superfamily of cytokines which has broad biological events like participation of immune response regulation, hematopoiesis, acute phase reactions, and oncogenesis. The purpose of this study was to evaluate the behavioral signifcance of IL-6 expression on oral squamous cell carcinoma cells. Fifty formalin fxed-paraffn embedded tissues of primary OSCCs were examined by immunohistochemistry for IL-6 expression. The expression scores of IL-6 then statistically correlated with different clinical and histopathological parameters to evaluate the possibility of IL-6 to change the behavior of OSCC cells. Positive expression of IL-6 was detected in 45 cases (90%) among them (31 cases; 62%) showed high level of expression, (14 cases; 28%) were low. only fve cases (10%) showed negative expression. Statistical analysis of this expression displayed non-signifcant relations with clinicopathological parameters studied. Top Keywords Oral squamous cell carcinoma, IL-6, prognosticators. Top |