Vitamin D Deficiency and First Trimester Miscarriage A Case Control Study Hassan Shaymaa Abd. Lecturer Department of Gynecology and Obstetrics, College of Medicine, Al-Iraqia University, Baghdad, Iraq Online published on 2 February, 2019. Abstract Background Miscarriage is the most common negative outcome of pregnancy, and identifcation of modifable risk factors is potentially of great importance for public health1. Vitamin D3 deficiency in pregnancy have been associated with some adverse pregnancy outcomes2. Miscarriage is reported to occur in about 12 to 20% of pregnancies. There are a number of different causes of miscarriage, including genetic and environmental factors. But There are Increasing evidence suggesting that low vitamin D3 levels may have an effect on miscarriage. Vitamin D plays an important role in regulating the immune system. Medivizor(2016) and its implicated in immune cell regulation at the feto-maternal interface and several diseases of pregnancy3. The objective of our study is to evaluate the effect of vitamine D3 deficiency on 1st miscarriages, in this study we tested the level of vitamin D3 in 89 female in 1sttrimester pregnancy and Follow up them till the end of 12 weeks gestation. Blood samples for serum vitamin D3 taken for each patients in at time of positive pregnancy test in serum4 weeks, then at 8 weeks and 12 weeks of gestation. Miscarriage occur in 16 females (17.9%), 6 of them had negative heart beat by ultrasound at 6–7 weeks, and 5 had miscarriage 8–10 weeks of gestation and the last 5 had miscarriage at 11–12 weeksof gestation, while 73 female (82%) had uneventful 1st trimester, the results show that the mean level for of serum vitamin D3 for miscarriage group was 17.3ng/dl, while for uneventful 1st trimester group was 30.5ng/dl. We concluded that vitamin D3 deficiency is associated with increasing incidence of 1st trimester miscarriages. Top Keywords vitamin D, 1st trimester miscarriage, defeciency. Top |