Usefulness of Serum total PSA Value in Screening of Various Prostratic Diseases Goel Anchit1, Mishra Jyoti2,*, Aggarwal Roopak3, Singh Natasha1, Deshmukh Geeta4 1Junior Resident, Department of Pathology, S.M.S.&R 2Assistant Professor, Department of Pathology, S.M.S. &R, Greater Noida 3Associate Professor, Department of Pathology, S.M.S. &R, Greater Noida 4Professor, Department of Pathology, S.M.S. &R, Greater Noida *Corresponding Author: Dr. Jyoti Mishra M.B.B.S. M.D. (Pathology) Assistant Professor, Department of Pathology, SMS&R, Greater Noida, Uttar Pradesh. Email: drm714@gmail.com Tel. No. +91-7503783590
Online published on 3 April, 2018. Abstract Background Prostate cancer is one of the common malignancy in males in India. Prostate Specific Antigen (PSA) is currently the best screening modality available for the detection of prostrate carcinoma. Aims & Objective To determine the correlation of total PSA levels in different Prostatic lesions. Materials & Method This prospective analytical study was conducted over a period of one year (June 2015 to May2016) in the department of Pathology, SMS&R Greater Noida. Total PSA estimation was done in all prostratic lesions immunometrically on Vitros ECi system. results All cases of adenocarcinoma showed total PSA ranging from 54.1–94.1 ng/ml except one which exhibited normal level of PSA of 5.6 ng/ml. There was one case of urothelial carcinoma which showed low serum PSA level of 2.4 ng/ml. In HGPIN total PSA level ranged from 45.4–58.6 ng/ml while in LG PIN PSA varied from 9.2–17.1 ng/ml. In non-neoplastic lesions it ranged from 3.76–6.62 ng/ml and it showed increase with an increase age. Conclusion The total PSA level of more than 54 ng/ml is highly suggestive of malignancy while 45–50 ng/ml were suggestive of HGPIN. Such cases should be thoroughly searched for malignancy. Top Keywords prostate specific antigen, prostate cancer, screening, immunometric assay. Top |