Analysis of Methanolic extract of Secondary Metabolites Released by Candida glabratus using GC-MS and Evaluation of Its Antimicrobial Activity Hamza Lena Fadhil1, Sahi Nebras M2, Hameed Imad Hadi3,* 1College of Pharmacy 2Department of Biology, College of Science for Women, University of Babylon, Hillah City, Iraq 3Biomedical Science Department, University of Babylon, College of Nursing, Hillah City, Iraq *Corresponding author: Imad Hadi Hameed Biomedical Science Department, University of Babylon, College of Nursing, Hillah city, Iraq; Phone number: Mob.: 009647716150716; E-mail: imad_dna@yahoo.com
Online published on 3 April, 2018. Abstract The objectives of this study were analysis of the secondary metabolite products and evaluation antibacterial and antifungal activity. Bioactives are chemical compounds often referred to as secondary metabolites. Thirty nine bioactive compounds were identified in the methanolic extract of Candida glabratus. The identification of bioactive chemical compounds is based on the peak area, retention time molecular weight and molecular formula. Coriandrum sativum was very highly antifungal activity (6.80±0.25)mm. The results of anti-fungal and anti-bacterial activity produced by Candida glabratus showed that the volatile compounds were highly effective to suppress the growth of Penicillium expansum (5.95±0.20) and Escherichia coli (5.900±0.22). Top Keywords Candida glabratus, GC-MS, Antifungal and Antibacterial, Secondary metabolites. Top |