Cytomegalovirus Pneumonia In Critically Ill Patients Singh Gurmeet1,2,* 1Respirology and Critical Illness Division Internal Medicine Department, Universitas Indonesia 2Faculty of Medicine, Cipto Mangunkusumo Hospital, Jl. Diponegoro No 71, Central Jakarta, 10430, Indonesia *Corresponding Author: Gurmeet Singh Jl. Diponegoro No 71, Central Jakarta, 10430, Indonesia Phone number: +62 (21-3149704) Facsimile number: +62 (21-31902461) E-mail adress: gurmeetsingh10@yahoo.com
Online published on 5 May, 2018. Abstract Cytomegalovirus (CMV) belongs to the human ß-herpes virus group with a high seroprevalence in adults, and it is one of the important causes of morbidity and mortality in immunosuppressed patients, i.e, patients with organ transplantation, hematology malignancy and Acquired Immune Deficiency Syndrome (AIDS). The infection is usually latent. Reactivation also occurs in critically ill immunocompetent patients and is associated with prolonged ICU stay and increased mortality. Reactivation occurs when cell mediated immunity is disturbed. Cytomegalovirus infection is rarely monitored and remains unrecognized in critical ill patients1, 2 and CMV incidence is between 0 to 36% in the critically ill population. Infection usually occurs between four to 12 days after hospitalization in ICU with sepsis, mechanical ventilation more than 21 days, and multiple blood transfusions as potential risk factors for CMV reactivation.3 Rapid and accurate diagnosis of the etiology of pneumonia is needed in critically ill patients for a better outcome.4 Cytomegalovirus infection can be detected in tissue biopsy and rapid Polymerase Chain Reaction (PCR) CMV cultures of urine and bronchoalveolar lavage (BAL) fluid with shell vial method.5 Top Keywords Bronchoalveolar Lavage, Cytomegalovirus Pneumonia, Polymerase Chain Reaction. Top |