A systematic review to assess the effectiveness and safety of nerve reconstruction using absorbable synthetic nerve conduit Park Jeong-Su1,*, Ko Ryeo-Jin2 1Assistant Professor, Dep. Korean Preventive Medicine, Semyung Univ., Jecheon, Korea 2Associate Research Fellow, Div. New Health Technology Assessment, National Evidence-based Healthcare Collaboration Agency, Seoul, Korea *Corresponding Author: Jeong-Su Park Assistant professor Department of Korean Preventive Medicine, Semyung University, Korea Email: suyahpark@gmail.com
Online published on 16 October, 2018. Abstract This study aimed to assess the effectiveness and safety of absorbable synthetic nerve conduit through systematic review. The search strategy was embodied according to PICO (patient, intervention, comparison, and outcome). The patients were with peripheral nerve damage and neuroma. The intervention was nerve reconstruction with absorbable synthetic nerve conduit. Comparisons were autologous nerve graft and end-to-end suturing. The safety outcome was procedure-related complications. The effectiveness outcomes were nerve function tests, procedure failure rate, and subjective assessment. A total number of 434 papers were searched, five studies included. The safety outcomes reported higher in the intervention group in clinical trial including wound healing problems and debridement of the wound. The effectiveness results were improved in the intervention group, but not significant in comparative study. In case series and case reports, the efficacy outcomes were different among articles. Nerve reconstruction using absorbable synthetic nerve conduit was needed further study, nevertheless it is expected to be clinically useful. Top Keywords Nerve defect, nerve conduit, nerve reconstruction, safety, effectiveness. Top |