Effects of pre-medication with dexmedetomidine, midazolam-butorphanol and their combination on propofol total intravenous anaesthesia in goats Negi B., Bodh D.* Department of Surgery and Radiology, College of Veterinary and Animal Sciences, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar-263 145, Uttarakhand *E-mail address: deeptibodh@yahoo.in
Online Published on 12 February, 2024. Abstract A study was conducted to compare the effects of dexmedetomidine (DEX), midazolambutorphanol (MID-BUT) and dexmedetomidine-midazolam-butorphanol (DEX-MID-BUT) premedication on the quality of sedation, induction, recovery and maintenance doses of propofol during total intravenous anaesthesia (TIVA) in goats. Eighteen goats were randomly divided into three groups. Premedication was done with DEX (@ 5 μg/kg body weight, IV) in Gr A, MID-BUT (@ 0.3 mg/kg + 0.2 mg/kg body weight, IV) in Gr B and A+B mixed in a single syringe in Gr C. All the goats were induced with propofol (@ 2 mg/kg body weight, IV) and maintained with intermittent intravenous injections of propofol till the end of closing last skin suture. Time to onset of sedation was significantly (P<0.05) lower in Gr C (9.50±1.34 sec) as compared to Gr B (12.33±1.78 sec). Time to onset of induction was significantly (P<0.05) lower in Gr C (11.33±0.67 sec) as compared to GrA (68.33±7.49 sec) and B (57.17±5.34 sec). Significantly (P<0.05) lower dose of propofol (2.18±0.00 and 8.08±1.37mg/kg) was needed for induction and maintenance in Gr C as compared to Gr A (3.23±0.44 and 13.27±1.36 mg/kg) and B (3.35±0.08 and 19.92±1.48 mg/kg). All goats remained calm during induction and recovery in all treatments. Physiological parameters were within clinically acceptable limits in all groups. No incidence of apnoea and regurgitation were reported in any group. It was inferred that dexmedetomidine-midazolam-butorphanol combination has more dose-sparing effect and provides adequate sedation and analgesia compared to DEX or MID-BUT in goats undergoing propofol TIVA. Top Keywords Butorphanol, Dexmedetomidine, Goats, Intravenous anaesthesia, Midazolam, Propofol. Top |