Risk Factors and Outcome of Staphylococcus Bloodstream Infection in Pediatric Hospital Zaki Maysaa E.l. Sayed1,*, El-Aziz Ahmed Ahmed Abd2, El-Banna Tarek El-Said2, Sallam Wedian Salem Ahmed3 1Professor of Clinical Pathology 2Professor of Microbiology, Faculty of Pharmacy, Tanta University, Egypt 3Pharmacist- Mansoura University Hospital, Egypt *Corressponding Author: may_s65@hotmail.com
Present Address: Professor of Clinical Pathology and Head of Clinical Microbiology Laboratories at Mansoura University Children Hospital, Egypt
Online published on 20 July, 2012. Abstract The goal of this study is to evaluate the pattern of Gram-positive bacteremia among children, with emphasis on causative organisms, underlying conditions, predisposing risk factors for infection and outcome. The study evaluated children admitted to hospital. Among 1432 patients 110 were affected by blood stream infection due to Gram positive cocci. Full microbiological study of Gram positive cocci were performed with evaluations of risk factors and outcome of those patients Results suggest that Gram-positive bacteremia is a major health problem and affects 7.7% of total hospitalizations. Coagulase-negative Staphylococci were the most prevalent organisms. Both Staphylococci aureus (S.aureus) and coagulase-negative Staphylococci show unusually decreased susceptibilities to most widely used antibiotics, including vancomycin. The percentage of methicillin-resistant isolates was 90% and 95.6% in S.aureus and coagulase-negative Staphylococci respectively and vancomycin-resistance percentage was 18.8% among Staphylococci. Most infections and poor outcome were associated with severe life-threatening underlying conditions. Neonates in particular were at high risk of death following Gram-positive bacteremia. Vancomycin resistance in Staphylococci, immunosuppression, recent surgical procedures and malnutrition are also statistically significant predictors for fatal outcome in children following Grampositive bacteremia. Special attention should be directed towards these populations upon admission to improve their prognosis. Further emphasis should be placed on blood stream infection caused by coagulase negative Staphylococci especially in high risk groups of pediatrics like neonates. Control measures to prevent MRSA spreading and vancomycin resistant Staphylococci. It may be also necessary to investigate other therapeutic alternatives for glycopeptides for treatment of severe staphylococcal bacteremia Top Keywords Blood stream infection, Risk factors, Staphylococcal species. Top |