Evaluation of antidiarrheal efficacy of traditionally used plants in rats and dairy calves Srivastava Ashish1, Mondal Deb Brat2, Sharma Nitika3,*, Mishra Anil Kumar3 1College of Veterinary Sciences & Animal Husbandry, U P Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan (DUVASU), Mathura, India 2ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, India 3ICAR-Central Institute for Research on Goats, Makhdoom, Mathura, India *Corresponding author: N Sharma; E-mail: nitika4419@gmail.com
Online Published on 30 December, 2022. Abstract Plants have been used since time immemorial to treat a variety of diseases. The present study was conducted to comparatively evaluate the antidiarrheal efficacy of plants traditionally used to treat diarrhea viz. semi ripe fruit of Aegle marmelos, rhizome of Curcuma longa, leaves of Dalbergia sissoo, bark of Mangifera indica, leaves of Psidium guajava and fruit rind of Punica granatum. Methanolic plant extracts were tested for their antidiarrheal efficacy in castor oil induced diarrhoea in rats at three different doses (@ 100, 200 and 400 mg/Kg body weight). Of the six extracts tested, Aegle marmelos fruit extract was found to be the most effective, followed by Dalbergia sissoo leaf extract; both resulted in dose dependent inhibition of diarrhea in rats. A. marmelos fruit extract was further evaluated for its therapeutic potential in acute undifferentiated diarrhea of calves @ 400 mg/Kg/Day, orally in two divided doses. Efficacy of the methanolic extract of Aegle marmelos was found comparable to that of oral pefloxacin given to a group of calves @ 10 mg/Kg body weight, orally, once a day. In conclusion, Aegle marmelos can effectively be used as a non-specific antidiarrheal in acute diarrhea of cattle calves. Highlights • Comparative evaluation of antidiarrheal efficacy of methanolic extracts of traditionally used plants in in rats and neonatal dairy calves. • Aegle marmelos can effectively be used as a non-specific antidiarrheal in acute undifferentiated diarrhea of cattle calves. Top Keywords Aegle marmelos, Antidiarrheal, Calf, Dairy calves, Dalbergia sissoo, Diarrhea, Rats. Top |