Status of Maternal Derived Antibody Against Rabies in Naive Puppies in Chennai Sowmiya M.1, Asokkumar M.1,*, Bharathi M. Vijaya1, Rathnapraba S.2, Kumar R.L. Senthil3, Devi T.1, Nagarajan B.1 1Department of Veterinary Preventive Medicine, Madras Veterinary College, TANUVAS, Chennai, Tamil Nadu, India 2Department of Animal Biotechnology, Madras Veterinary College, TANUVAS, Chennai, Tamil Nadu, India 3Indian Immunologicals Ltd., Hyderabad, India *Corresponding author: AM Kumar; E-mail: drashokpmd@gmail.com
Online published on 3 December, 2019. Abstract Thirty-six blood samples were collected randomly from puppies [18 puppies each from vaccinated (Group I) and unvaccinated (Group II) dam] brought to Immunization Unit, Madras Veterinary College Teaching Hospital, Chennai. The samples were subjected to functional antibody assay (RFFIT) to know the kinetics of maternal derived antibody (MDA) against rabies. The mean MDA titre in group I and II puppies were found as 1.07 ± 0.18 IU/mL and 0.30 ± 0.037 IU/mL respectively. The statistical analysis (Student “t” test) revealed a highly significant difference (P<0.01) between MDA of two groups. Thus, this study strongly suggests that the dogs less than three months of age in endemic regions needs to be immunized against rabies in view of maintaining the population immunity and to reduce the bioburden of rabies risk. Top Keywords MDA, Puppies immunization, Rabies, RFFIT. Top |