Serological response of dromedary camels vaccinated with Brucella abortus RB51 and Brucella melitensis REV 1 Vaccines Wernery U, Caveney M Rodriguez, Jose Sh, Johnson B, Raghavan R, Christopher J, Syriac G, Thomas Sh M, Paily N M Central Veterinary Research Laboratory, P O Box 597, Dubai, UAE Online published on 26 September, 2019. Abstract A vaccination experiment was conducted in dromedary camels at CVRL. Six adult dromedaries received 2 ml of the Brucella abortus vaccine RB51 subcutaneously and 6 camels 1ml of the B. melitensis Rev 1. Four different serological tests were conducted to follow the seroconversion post vaccination. None of the 6 dromedaries vaccinated with RB51 produced antibodies, measured for 1 year, due to lack of lipopolysaccharide O-side chains in the vaccine. However, antibodies appeared in all 6 dromedaries 30 days post vaccination with B. melitensis Rev 1, which declined slowly over time. Three hundred thirty days post vaccination ELISA antibodies were still present in 5 of the 6 dromedaries as well as RBT, SAT and CFT antibodies in some of them. This is a disadvantage as all serological methods for the diagnosis of brucellosis cannot differentiate between vaccine or natural infection titres. Top Keywords Antibodies, Brucella abortus RB51, Brucella melitensis, serology, vaccination against brucellosis. Top |