Genome Wide Association Studies for Milk Nutrition Traits in Gobi Red Bactrian Camel Gubin1, Lixin2, Wusutiannan3, Qimude4, Lihushan5, Liyi5, Song Haiyan6, Liang Ming7,*, Hasi1, Jirenduribu1, Baolide3 1Agriculture, Animal Husbandry and Science and Technology Bureau of Ured Rear Banner, Inner Mongolia015543, China 2Animal Disease Prevention and Control Centre of Ured Rear Banner, Inner Mongolia015543, China 3Ured Rear Banner People’s Government, Inner Mongolia015543, China 4Ured Rear Banner Livestock and Aquatic Workstation, Inner Mongolia015543, China 5Bayannur City Animal Husbandry Service Centre, Inner Mongolia015000, China 6Bayannur City Animal Husbandry Service Centre, Inner Mongolia015000, China 7Key Laboratory of Dairy Biotechnology and Bioengineering, Ministry of Education, College of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot010018, China *SEND REPRINT REQUEST TO MING LIANG email: yeluotuo1999@vip.163.com
Online Published on 25 December, 2023. Abstract Through our research, we explored a suite of novel single nucleotide polymorphisms (SNPs) associated with milk nutrition traits, and thus form a solid basis for eventually unraveling the causal mutations for milk production traits in the Bactrian camel. A genome-wide association study was conducted for four general nutritional indicators (milk lactose, dry matter, milk protein, and milk fat) and the composition of 17 amino acids in 158 Gobi Red Bactrian camels (Camelus bactrianus). Genome-wide association study was performed on the 548745 SNPs identified by genotyping-by-sequencing. The phenotypes of the milk nutrient traits were determined and the association effects of single nucleotide polymorphisms SNPs on each phenotype were evaluated using a mixed effect linear model. One or more than one of the milk traits were significantly associated with 46 single nucleotide polymorphisms. All the polymorphic sites were located in intergenic regions or non-coding regions of genes in the genome. Two single nucleotide polymorphisms were significantly associated with camel milk lactose and protein, and were located in the OSBPL8, MRPL37, SSBP3, and LOC102516351 genes. The results of the present study will be used to reveal the genetic basis of milk nutrition traits in domestic Bactrian camels. Top Keywords Bactrian camel milk, Correlation analysis, Single nucleotide polymorphism. Top |