Antioxidant Activities of Cuminum cyminum Extracts and Their Antibacterial Effects against Some Dental Caries Pathogens Rebai Ouafa1,*, Benslimane Sabria2, Djibaoui Rachid2, Arabi Abed2 1Laboratory of Microbiology and Vegetal Biology, 2700, MosqataganemAlgeria 2Department of Biology, Faculty of Natural Sciences and Life, University Abdelhamid Ibn badis of Mostaganem, Algeria *Corresponding Author: Ouafa Rebai, Laboratory of Microbiology and Vegetal Biology, 2700, MosqataganemAlgeria, Email: rebaiouafa@yahoo.fr
Online Published on 06 January, 2024. Abstract Background The seeds of cumin (Cuminum cyminum L.) are widely used as the spice for their distinctive aroma, they are also commonly used in traditional medicine to treat a variety of diseases. Methods The present study aimed to evaluate the antioxidant activities of cumin extracts and their antimicrobial effects against six oral pathogens isolated from dental caries and supragingival plaque. The extracts were obtained by maceration with acetone, ethanol and methanol at 70% (v/v). Result The greatest content of polyphenols, flavonoids and tannins, was obtained with acetone (42±3.46 mg GAE/g DW), (24.49±1.24 mg EQ/g DW) and (34.95±8.71 mg EC/g DW) respectively. HPLC analysis performed to determine acetonic extract components revealed the presence of p-coumaric acid, diosmin as the most abundant compounds and several apigenins. Antioxidant activity of cumin extracts showed the greatest activity with the acetonic extract (940±42 µg/mL) followed very closely by the ethanolic extract (960±50 µg/mL). The agar well diffusion method has shown that all the extracts have an antimicrobial power against all the Gram+strains. The minimum inhibitory concentration values recorded by the studied extracts vary from 12.5 to 200 mg/mL. These findings suggest that cumin seed extracts might be effective as antibacterial agent against oral pathogens. Top Keywords Antioxidant activity, Antibacterial activities, Cuminum cyminum, Dental caries, Phenolic extracts. Top |