Black Seed Oil Improves Beef Fat-induced Blood-biochemical Abnormalities in Swiss Albino Mice Miah M.A.1,*, Roy D.1, Sujan K.M.1, Khalil K.K.I.2, Mustari A.1 1Department of Physiology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh 2Department of Physiology and Pharmacology, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur-1706, Bangladesh *Corresponding Author: M.A. Miah, Department of Physiology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh, Email: mam74@bau.edu.bd
Online Published on 06 January, 2024. Abstract Background The high saturated fatty acid content of beef has been linked to obesity and cardiovascular diseases. The study investigated the impact of black seed oil (BSO) on beef fat-altered hemato-biochemical and pathophysiological alterations in albino mice. Methods Twenty four Swiss Albino mice (Mus musculus) of 25-28 days old were equally divided into three groups (n=8) namely A, B and C. Mice of group A was designated as the untreated control group. Groups B and C were fed pellets containing 10% beef fat and 10% BSO, respectively for 9 weeks. Result The results revealed that beef fat-fed mice gained weight and BSO normalized the weight gain. The hematological values of beef fat supplemented mice improved after being supplemented with 10% BSO. LDL-c, Triglycerides and total cholesterol levels were all significantly lower in mice fed BSO plus beef fat. HDL-c levels were significantly higher in BSO plus beef fat-fed mice. Spleens in BSO plus beef fat-fed mice were slightly enlarged without gross abnormalities. 10% beef fat caused minor changes in the histostructures of the kidney, heart and liver. There were significant changes in cardiac muscle and massive fatty changes in kidney tissue. This study concluded that BSO has beneficial effects on the body and can prevent beef fat-induced abnormalities. Top Keywords Beef fat, Black seed oil, Blood-biochemical parameters, Mice. Top |