Efficacy of Tranexamic Acid with Hypotensive Anesthesia versus Hypotensive Anesthesia Alone on Intraoperative Blood Loss in Orthognathic Surgeries-A Comparative Study Challari Sasikanth1, Ranganath K.2, Patil Sudha1, Prasad Kavitha3, Sejal K.M.4, Sagar Parimala4 1ExPost Graduate Student, Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, M.S. Ramaiah University of Applied Sciences, Bangalore-560054 2Professor and Head Department Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, M.S. Ramaiah University of Applied Sciences, Bangalore-560054 3Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, M.S. Ramaiah University of Applied Sciences, Bangalore-560054 4Reader Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, M.S. Ramaiah University of Applied Sciences, Bangalore-560054 *Corresponding Author E-mail: sasikanth.challari@gmail.com
Online published on 24 January, 2020. Abstract Aim To evaluate the efficacy of tranexamic acid with and without hypotensive anaesthesia on intraoperative blood loss in orthognathic surgeries. Objectives To assess the amount of blood loss and need for any blood transfusion, quality of surgical field, duration of surgery and Pre-operative and post-operative Hb (g/dl). Methodology This study was carried out between November 2016 to October 2018 on patients reporting to Department of Oral and Maxillofacial Surgery and Department of Orthodontics and Dentofacial Orthopaedics, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Bengaluru, with skeletal malocclusion, requiring corrective surgeries like anterior maxillary osteotomy, LeFort 1 osteotomy, bilateral sagittal split osteotomy and genioplasty. Patients are divided into study and control group. Patients in Study group received tranexamic acid along with hypotensive anaesthesia and Patients in Control group received only hypotensive anaesthesia. Results We found significant reduction in the amount of blood loss, clear and better surgical field visibility in the study group when compared to the control group. The reduction in Hb (g/dl) levels was statistically significant in both the groups, there was no necessity of blood transfusion in either groups and there was not much variation observed in the duration of surgery amongst both the groups. Conclusion Tranexamic acid along with moderate hypotension is a safe, effective and economic protocol in reducing the blood loss and improving the quality of surgical field, thus allowing for easier, more deliberate and accurate dissection. Top Keywords Tranexamic Acid, Hypotensive Anesthesia, Orthognathic Surgery, . Top |