The morphological differences between acute tubular necrosis and autolysis: An autopsy study Castelino KP1, Devaraju S2, Bhat A3, Thattil AMT4,* 1Department of Forensic Medicine and Toxicology, Father Muller Medical College, Mangalore 2Department of Pathophysiology, College of Medicine - American University of Antigua, Osbourn, Antigua & Barbuda 3Department of Pathology, Father Muller Medical College, Mangalore 4Department of Community Medicine, Father Muller Medical College, Mangalore *Corresponding Author, Dr. Anissa Mary Thomas Thattil (Assistant Professor), Email: thomas.anissa@gmail.com / thomas.anissa@fathermuller.in, Mobile No.: +91 9108151069
Online Published on 2 January, 2024. Abstract The post-mortem identification of acute tubular necrosis (ATN) and autolysis poses a considerable challenge due to overlapping pathological features. This study was therefore conducted with the objective of identifying morphological characteristics that will assist in differentiating between ATN and autolysis in post-mortem renal specimens. This analytical study included all samples received by the department of Pathology from individuals who were clinically diagnosed as ATN and satisfying defined biochemical parameters. Age and sex matched control specimens were chosen from healthy individuals who suffered an accidental or sudden death and who satisfied defined exclusion criteria. Atotal of 82 samples were included. There were samples from 25 males and 16 females in each group. The mean age of the cases was 42.12 ± 18.27 years while the mean age of the control group was 49.65 ± 16.64 years. The gross weight of the kidneys was not found to be significantly different between the two groups. Three morphological characteristics were found to significantly vary between the cases and controls: cell vacuolation (P=0.029), hematopoietic cells in the vasa recta (P=0.003) and tubular epithelial whorls (P=0.0002). Of these, tubular epithelial whorls were found to have the highest validity (sensitivity=0.88, specificity=0.92). Tubular epithelial whorls can be used independently or in conjunction with other morphological criteria in order to accurately identify ATN in postmortem renal tissue. Top Keywords Acute tubular necrosis, Autolysis, Autopsy, Histology, Ischemia, Tubular epithelial whorls, Kidney, Renal, Vacuolation. Top |