Potency of Topical Curcumin in the Treatment of Oral Lichen Planus-A Randomized Clinical Trial Biswas Subrata1,*, Ranjan Vikash2, Arora Pallak2, Rastogi Trisha3 1PG Student, Department of Oral Medicine and Radiology, D.J. College of Dental Sciences and Research, Modinagar, Uttar Pradesh, India 2Reader, Department of Oral Medicine and Radiology, D.J. College of Dental Sciences and Research, Modinagar, Uttar Pradesh, India 3Senior Lecturer, Department of Oral Medicine and Radiology, D.J. College of Dental Sciences and Research, Modinagar, Uttar Pradesh, India *Address for correspondence: Subrata Biswas Email Id: subrata1206@gmail.com
Online published on 24 January, 2018. Abstract Background Lichen planus is the T-cell mediated autoimmune diseases that affect the skin and the mucous membrane. Corticosteroid are the most common drugs for Oral Lichen Planus management but because of the side effect it may be better to avoid the longterm use, thus trends toward drugs of natural origin like curcumin exhibits anti-oxidant, anti-inflammatory, antimicrobial and anticarcinogenic activities. Aim To assess the efficacy of topical curcumin in the treatment of symptomatic oral lichen planus. Materials and Methods In the present study 10 patients (3 men and 7 women) within the age range of 26–61 years were included. Each patient received 1% curcumin oral paste twice a day for 60 days. Assessment of severity of burning was done by VAS scale. Appearance score (sign score) was recorded among the study group based on the criteria given by Thongprasomk. Results With respect to reduction in burning sensation, 9 patients (90%) showed short complete remission. With respect to the appearance score, 9 patients (90%) showed complete remission. Conclusion Application of curcumin can be suggested for the treatment of Oral Lichen Planus because of its desirable anti-inflammatory and anti-oxidants affects and insignificant side effect. Top Keywords Anti-inflammatory, Anti-oxidants, Burning sensation, Corticosteroid, Curcumin, Lichen Planus, Management, T-cell. Top |