Histopathological investigations of ethanol extract of Syzygium luzonense (Merr.) Merr on Rattus norvegicus Astriani Meli1, Walean Mario2,*, Maliangkay Hendra Pratama3, Wardhani Sri1, Mahendra Reno Esa1 1Departement of Biology Education, Faculty of Teacher Training and Education, Universitas Muhammadiyah Palembang. Jl. Jend. Ahmad Yani 13 Ulu, Palembang30116, South Sumatra, Indonesia 2Faculty of Science and Technology, Universitas Prisma. Jl. Pomorow No. 113, Tikala Baru, Manado, 955126, North Sulawesi, Indonesia 3Pharmacy Study Program, University Trinita, Jl. Malalayang Satu Barat, Manado, North Sulawesi, Indonesia *Corresponding author e-mail: mario.walean@gmail.com
Online Published on 16 August, 2022. Abstract Syzygium luzonense (Pakoba) is an endemic plant of North Sulawesi part of Indonesia that is used for ethnomedical purposes in the treatment of diabetes, childbirth, kidney stone, and gastritis. The purpose of this study was to determine the acute effect of high doses of ethanol extract of pakoba stem bark (PSBEE) on the histology of several vital organs of wistar rats. The results from histopathological observations of several vital organs of test animals after administration of PSBEE at doses of 1,000, 5,000, 10,000, and 15,000 mg/kgbw for 14 days, showed no difference between all PSBEE treatment groups and the normal group. In general, the tissue structure of the liver, kidney, spleen, lungs, and gastric after administration of PSBEE was normal and there was no signs of acute toxicities. However, further subchronic toxicity studies are important to ensure the complete safety profile of PSBEE. Top Keywords Ethanol extract, Histopathology, Organs, Pakoba, Rattus norvegicus. Top |