Therapeutic potential of natural compounds in the treatment of obesity: A review on computational and experimental studies Athista M, Harsiddhi A, Nachiyar C Valli, Sunkar Swetha* Department of Bioinformatics, Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu, India *Corresponding author e-mail: swethauk78@gmail.com
Online Published on 31 March, 2023. Abstract Obesity has become a major cause of concern in the current health scenario due to the massive increase in obesity affecting people including women and children. Global statistics raise the question of well-being of future generations who are more prone to several disorders. Genetic causes, lifestyle changes, and environment are the key factors in obesity. Moreover, obesity is alarming as this leads to many other disorders in due course of time like hypertension, diabetes, osteoporosis, etc. Treatment strategies currently available offer some respite to the problem but available drugs do come with certain side effects when consumed for a long period. Therefore, alternative methods of treating and managing the disease are on the rise. Natural compounds from various sources like plants and microbes offer potential in this area as they are a storehouse of structurally diverse metabolites that have varied applications from medicine to industry. The usage of these compounds requires a preliminary study of their structure and properties that can be studied using in silico methods after which experiments will be carried out to validate their activity. This review summarizes the in silico, in vitro and in vivo studies in obesity using natural compounds. Top Keywords Naturopathy, Genetic factors, Medicine, Drugs, Antiobesity. Top |