Medicinal Plants - International Journal of Phytomedicines and Related Industries
Year : 2010, Volume : 2, Issue : 1
First page : ( 63) Last page : ( 66)
Print ISSN : 0975-4261. Online ISSN : 0975-6892.
Article DOI : 10.5958/j.0975-4261.2.1.009

Polyphenol analysis and anti-tumor activity of crude extracts from tegmen of Artocarpus heterophyllus

Rajendran Nanda Kumar*, Ramakrishnan Jayapradha

School of Chemical and Biotechnology, SASTRA University, Thanjavur, 613 402, India.

*Corresponding author: Nanda Kumar Rajendran, E-mail: nandabiotech@yahoo.com

Abstract

Artocarpus heterophyllus are rich sources of the isoprenylated phenolic compounds, including flavonoids. In this study, crude extracts from the tegmen of A. heterophyllus were tested in vitro for their antitumor activity. Total polyphenol content of the extracts ranged from 97.33 to 117.75mg gallic acid equivalent (GAE)/g extract depending on the solvent used and extraction time applied. Among the three solvent extracts, methanol extract showed maximum polyphenol content at 2 hr extraction time followed by ethanol and butanol respectively. The methanolic extract showed maximum cytotoxicity on HEp2 cells up to 1:4 dilution. Cytotoxic changes observed was cell aggregation, cell rounding & cell death. The overall results indicate promising baseline information for the potential uses of crude extract from the tegmen of A. heterophyllus as an antitumor agent.

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Keywords

Artocarpus heterophyllus, tegmen, polyphenol, antitumor and HEp2 cells.

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